Gastric/Esophageal Trials
PCYC-1128-CA
PCYC-1128-CA – A phase1b/2 study of ibrutinib combination therapy in selected advanced gastrointestinal and genitourinary tumors – bladder, colon, gastric, renal
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What type of cancer? What stage?
- Advanced GI cancer – gastric and colon
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Who is eligible?
- Patients who have received prior chemotherapy
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How will I be treated?
- Patients will receive ibrutinib with other chemotherapy or biologic therapy
S0820
S0820 – Phase III a double blind placebo-controlled trial of eflornithine and sulindac to prevent recurrence of high risk adenomas and second primary colorectal cancers in patients with stage 0-3 colon cancer
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What type of cancer? What stage?
- Colorectal cancers or high-rick adenomas - polyps.
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Who is eligible?
- Patients with stage 0, 1, 2, or 3 disease that is removed who desire prevention
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How will I be treated?
- This study looks at using two drugs for prevention – Sulindac, non-steriodal anti-inflammatory, and eflornithine is a drug that has been shown in a preclinical data to have a role in cancer prevention.
CX-839-008
CX-839-008 – A phase III, randomized, placebo controlled study of Atezolizumab (Anti-PD-L1 Antibody) as monotherapy and in combination with platinum chemotherapy with untreated locally advanced or metastatic urothelial carcinoma
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What type of cancer? What stage?
- Renal cell cancer
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Who is eligible?
- Patients with disease progression after first-line therapy
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How will I be treated?
- Adds CB-839 - a drug that inhibits tumor cell nutrient uptake - to treated with Cabozantinib - a small molecule tyrosine kinase inhibitor.
For physicians: more information about this specific trial at clinicaltrials.gov.
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